54(4), 2007, pp.1003-1010

Synthesis and Biological Activity of Mercaptobenzoxazole Based Thiazolidinones and Their Arylidenes

P. Kohli,* S. D. Srivastava and S. K. Srivastava

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar (M.P.) 470 003, India

Abstract.     Arylidenes of thiazolidines with mercaptobenzoxazole, namely[(aryl-4-oxo-1,3-thiazolidin)-hydrazinoacetyl-mercaptobenxazole]; (5-arylidene)-2-aryl-4-oxo-1,3-thiazoliden hydrazinoacetyl-mercaptobenxazole were synthesized. Their chemical structures have been confirmed by 1H NMR, IR, mass spectra and also by microanalytical data. Antimicrobial evaluation was done by agar dilution method against three pathogenic bacteria viz. Bacillus subtilis, Escherichia coli and Klebsiella pneumoniae and three pathogenic fungi viz. Aspergillus niger, Candida albicans and Fusarium oxysporum. Among new derivatives evaluated, the chloro derivatives exhibited higher potency as compared to the standard drugs streptomycin (for bacteria) and griseofulvin (for fungi) against the tested organisms.

Keyword:  Thiazolidines; Mercaptobenzoxazole; Antimicrobial agent.