54(4), 2007, pp.1053-1066

Synthesis of Thiophenes, Azoles and Azines with Potential Biological Activity by Employing the Versatile Heterocyclic Precursor N-Benzoycyanoacetylhydrazine

Rafat M. Mohare,* Jonathan Z. Ho and Fatma O. Alfarouk

Department of Chemistry, Faculty of Science, Cairo University, Giza, A. R. Egypt

Abstract.     This research work is concerned with the use of N-benzoyl cyanoacetylhydrazine (3) in synthesizing several new heterocyclic compounds with potential biological activity, via its reaction with various chemical reagents. The synthesized derivatives have actually exhibited, upon screening, antibacterial and antifungal activities.

Keyword:  N-Benzoylhydrazide; Thiophene; Thiazole; Coumarin.